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The molecule is classified as a triple receptor agonist, which means it interacts with the glucagon like peptide 1 receptor (GLP 1R), glucose dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

The side effects are similar to semaglutide GLP-1, primarily gastrointestinal discomfort

In a recent clinical study, we reported that the expression of GLP-1R on macrophages, especially M2 marcrophages, was significantly reduced in patients with coronary heart disease (CHD), suggesting a potential role of macrophage-derived GLP-1R signaling in cardiovascular disease (38)

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